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1.
CEUR Workshop Proceedings ; 3380, 2022.
Artigo em Inglês | Scopus | ID: covidwho-20238595

RESUMO

The detection of temporal abnormal patterns over streaming data is challenging due to volatile data properties and lacking real-time labels. The abnormal patterns are usually hidden in the temporal context, which can not be detected by evaluating single points. Furthermore, the normal state evolves over time due to concept drift. A single model does not fit all data over time. Autoencoders are recently applied for unsupervised anomaly detection. However, they usually get expired and invalid after distributional drifts in the data stream. In this paper, we propose an autoencoder-based approach (STAD) for anomaly detection under concept drift. In particular, we use a state-transition-based model to map different data distributions in each period of the data stream into states, thereby addressing the model adaptation problem in an interpretable way. We empirically demonstrate the state transition process and evaluate the anomaly detection performance on the Covid-19 dataset of Germany. © 2022 Copyright for this paper by its authors. Use permitted under Creative Commons License Attribution 4.0 International (CC BY 4.0). CEUR Workshop Proceedings (CEUR-WS.org)

2.
Concurrency and Computation: Practice and Experience ; 2023.
Artigo em Inglês | Scopus | ID: covidwho-2323991

RESUMO

In this article, the detection of COVID-19 patient based on attention segmental recurrent neural network (ASRNN) with Archimedes optimization algorithm (AOA) using ultra-low-dose CT (ULDCT) images is proposed. Here, the ultra-low-dose CT images are gathered via real time dataset. The input images are preprocessed with the help of convolutional auto-encoder to recover the ULDCT images quality by removing noises. The preprocessed images are given to generalized additive models with structured interactions (GAMI) for extracting the radiomic features. The radiomic features, such as morphologic, gray scale statistic, Haralick texture are extracted using GAMI-Net. The ASRNN classifier, whose weight parameters optimized with Archimedes optimization algorithm enables COVID-19 ULDCT images classification as COVID-19 or normal. The proposed approach is activated in MATLAB platform. The proposed ASRNN-AOA-ULDCT attains accuracy 22.08%, 24.03%, 34.76%, 34.65%, 26.89%, 45.86%, and 32.14%;precision 23.34%, 26.45%, 34.98%, 27.06%, 35.87%, 34.44%, and 22.36% better than the existing methods, such as DenseNet-HHO-ULDCT, ELM-DNN-ULDCT, EDL-ULDCT, ResNet 50-ULDCT, SDL-ULDCT, CNN-ULDCT, and DRNN-ULDCT, respectively. © 2023 John Wiley & Sons, Ltd.

3.
3rd International Conference on Artificial Intelligence and Computer Engineering, ICAICE 2022 ; 12610, 2023.
Artigo em Inglês | Scopus | ID: covidwho-2323482

RESUMO

Global pandemic due to the spread of COVID-19 has post challenges in a new dimension on facial recognition, where people start to wear masks. Under such condition, the authors consider utilizing machine learning in image inpainting to tackle the problem, by complete the possible face that is originally covered in mask. In particular, autoencoder has great potential on retaining important, general features of the image as well as the generative power of the generative adversarial network (GAN). The authors implement a combination of the two models, context encoders and explain how it combines the power of the two models and train the model with 50,000 images of influencers faces and yields a solid result that still contains space for improvements. Furthermore, the authors discuss some shortcomings with the model, their possible improvements, as well as some area of study for future investigation for applicative perspective, as well as directions to further enhance and refine the model. © 2023 SPIE.

4.
ACM Transactions on Management Information Systems ; 13(1), 2021.
Artigo em Inglês | Scopus | ID: covidwho-2326987

RESUMO

(Aim) COVID-19 has caused more than 2.28 million deaths till 4/Feb/2021 while it is still spreading across the world. This study proposed a novel artificial intelligence model to diagnose COVID-19 based on chest CT images. (Methods) First, the two-dimensional fractional Fourier entropy was used to extract features. Second, a custom deep stacked sparse autoencoder (DSSAE) model was created to serve as the classifier. Third, an improved multiple-way data augmentation was proposed to resist overfitting. (Results) Our DSSAE model obtains a micro-averaged F1 score of 92.32% in handling a four-class problem (COVID-19, community-acquired pneumonia, secondary pulmonary tuberculosis, and healthy control). (Conclusion) Our method outperforms 10 state-of-the-art approaches. © 2021 Copyright held by the owner/author(s). Publication rights licensed to ACM.

5.
International Journal of Pattern Recognition & Artificial Intelligence ; : 1, 2023.
Artigo em Inglês | Academic Search Complete | ID: covidwho-2319097

RESUMO

COVID-19 is known in recent times as a severe syndrome of respiratory organ (Lungs) and has gradually produced pneumonia, a lung disorder all around the world. As coronavirus is continually spreading rapidly globally, the computed tomography (CT) technique has been made important and essential for quick diagnosis of this dangerous syndrome. Hence, it is necessitated to develop a precise computer-based technique for assisting medical clinicians in identifying the COVID-19 influenced patients with the help of CT scan images. Therefore, the multilayer perceptron neural networks optimized with Garra Rufa Fish optimization using images of CT scan is proposed in this paper for the classification of COVID-19 patients (COV-19-MPNN-GRF-CTI). The input images are taken from SARS-COV-2 CT-scan dataset. Initially, the input images are pre-processed utilizing convolutional auto-encoder (CAE) to enhance the quality of the input images by eliminating noises. The pre-processed images are fed to Residual Network (ResNet-50) for extracting the global and statistical features. The extraction over the features of CT scan images is made through ResNet-50 and subsequently input to multilayer perceptron neural networks (MPNN) for CT images classification as COVID-19 and Non-COVID-19 patients. Here, the layer of Batch Normalization of the MPNN is separated and added with ResNet-50 layer. Generally, MPNN classifier does not divulge any adoption of optimization approach for calculating the optimal parameters and accurately classifying the extracted features of CT images. The Garra Rufa Fish (GRF) optimization algorithm performs to optimize the weight parameters of MPNN classifiers. The proposed approach is executed in MATLAB. The performance metrics, such as sensitivity, precision, specificity, F-measure, accuracy and error rate, are examined. Then the performance of the proposed COV-19-MPNN-GRF-CTI method provides 22.08%, 24.03%, 34.76% higher accuracy, 23.34%, 26.45%, 34.44% higher precision, 33.98%, 21.95%, 34.78% lower error rate compared with the existing methods, like multi-task deep learning using CT image analysis for COVID-19 pneumonia classification and segmentation (COV-19-MDP-CTI), COVID-19 classification utilizing CT scan depending on meta-classifier approach (COV-19-SEMC-CTI) and deep learning-based COVID-19 prediction utilizing CT scan images (COV-19-CNN-CTI), respectively. [ FROM AUTHOR] Copyright of International Journal of Pattern Recognition & Artificial Intelligence is the property of World Scientific Publishing Company and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full . (Copyright applies to all s.)

6.
Int J Mol Sci ; 24(9)2023 Apr 29.
Artigo em Inglês | MEDLINE | ID: covidwho-2312525

RESUMO

Over the past three years, significant progress has been made in the development of novel promising drug candidates against COVID-19. However, SARS-CoV-2 mutations resulting in the emergence of new viral strains that can be resistant to the drugs used currently in the clinic necessitate the development of novel potent and broad therapeutic agents targeting different vulnerable spots of the viral proteins. In this study, two deep learning generative models were developed and used in combination with molecular modeling tools for de novo design of small molecule compounds that can inhibit the catalytic activity of SARS-CoV-2 main protease (Mpro), an enzyme critically important for mediating viral replication and transcription. As a result, the seven best scoring compounds that exhibited low values of binding free energy comparable with those calculated for two potent inhibitors of Mpro, via the same computational protocol, were selected as the most probable inhibitors of the enzyme catalytic site. In light of the data obtained, the identified compounds are assumed to present promising scaffolds for the development of new potent and broad-spectrum drugs inhibiting SARS-CoV-2 Mpro, an attractive therapeutic target for anti-COVID-19 agents.


Assuntos
Inteligência Artificial , Tratamento Farmacológico da COVID-19 , Proteases 3C de Coronavírus , Descoberta de Drogas , Bibliotecas de Moléculas Pequenas , Modelos Moleculares , Bibliotecas de Moléculas Pequenas/farmacologia , Bibliotecas de Moléculas Pequenas/uso terapêutico , Proteases 3C de Coronavírus/antagonistas & inibidores , Descoberta de Drogas/métodos , Redes Neurais de Computação
7.
Pneumologie ; 77(Supplement 1):S41-S42, 2023.
Artigo em Inglês | EMBASE | ID: covidwho-2291640

RESUMO

The ongoing corona virus disease 2019 (COVID-19) pandemic has led to an urgent demand for appropriate models depicting host-pathogen interactions and disease severity-dependent immune responses. Amongst various animal models, hamster species are particularly valuable as they are permissive to develop a moderate (Mesocricetus auratus) or severe (Phodopus roborovskii) disease course following infection. Here, we use single-cell ribonucleic acid sequencing of white blood cells to dissect cell-specific changes in moderate and severe disease courses of hamsters infected with severe acute respiratory syndrome coronavirus 2. To determine universal and species-specific transcriptional responses, the generated datasets were integrated with two publicly available datasets of human COVID-19 patients (Schulte-Schrepping et al. 2020 and Su et al. 2020) featuring all disease severities. Datasets were integrated using the R package Harmony and the Python package scGen enabling the prediction of disease states through different species using an autoencoder neural network architecture. Specifically, application of a low dimensional latent space embedding allows capturing most relevant transcriptome data structures, identifying shift vectors from healthy to diseased cells as well as interspecies differences. Preliminary results show that interspecies integration of hamster and human data is achievable, and major cell types were identified throughout the datasets. Training of a neuronal network on human blood monocytes enables the prediction of transcriptomic disease severity specific patterns, paving the way for extended analyses involving several cell types and species. In addition to in-depth analysis of COVID-19 signatures in blood of hamsters and humans, successfully established workflows could subsequently be used to study the pathology of extensive lung diseases, shedding light on cellular mechanisms in the transition from healthy to diseased cellular states.

8.
Expert Syst Appl ; 225: 120104, 2023 Sep 01.
Artigo em Inglês | MEDLINE | ID: covidwho-2291741

RESUMO

The detection of the COronaVIrus Disease 2019 (COVID-19) from Computed Tomography (CT) scans has become a very important task in modern medical diagnosis. Unfortunately, typical resolutions of state-of-the-art CT scans are still not adequate for reliable and accurate automatic detection of COVID-19 disease. Motivated by this consideration, in this paper, we propose a novel architecture that jointly affords the Single-Image Super-Resolution (SISR) and the reliable classification problems from Low Resolution (LR) and noisy CT scans. Specifically, the proposed architecture is based on a couple of Twinned Residual Auto-Encoders (TRAE), which exploits the feature vectors and the SR images recovered by a Master AE for performing transfer learning and then improves the training of a "twinned" Follower AE. In addition, we also develop a Task-Aware (TA) version of the basic TRAE architecture, namely the TA-TRAE, which further utilizes the set of feature vectors generated by the Follower AE for the joint training of an additional auxiliary classifier, so to perform automated medical diagnosis on the basis of the available LR input images without human support. Experimental results and comparisons with a number of state-of-the-art CNN/GAN/CycleGAN benchmark SISR architectures, performed by considering × 2 , × 4 , and × 8 super-resolution (i.e., upscaling) factors, support the effectiveness of the proposed TRAE/TA-TRAE architectures. In particular, the detection accuracy attained by the proposed architectures outperforms the corresponding ones of the implemented CNN, GAN and CycleGAN baselines up to 9.0%, 6.5%, and 6.0% at upscaling factors as high as × 8 .

9.
New Gener Comput ; : 1-36, 2022 Nov 19.
Artigo em Inglês | MEDLINE | ID: covidwho-2293186

RESUMO

Early and fast detection of disease is essential for the fight against COVID-19 pandemic. Researchers have focused on developing robust and cost-effective detection methods using Deep learning based chest X-Ray image processing. However, such prediction models are often not well suited to address the challenge of highly imabalanced datasets. The current work is an attempt to address the issue by utilizing unsupervised Variational Auto Encoders (VAEs). Firstly, chest X-Ray images are converted to a latent space by learning the most important features using VAEs. Secondly, a wide range of well established data resampling techniques are used to balance the preexisting imbalanced classes in the latent vector form of the dataset. Finally, the modified dataset in the new feature space is used to train well known classification models to classify chest X-Ray images into three different classes viz., "COVID-19", "Pneumonia", and "Normal". In order to capture the quality of resampling methods, 10-folds cross validation technique is applied on the dataset. Extensive experimental analysis have been carried out and results so obtained indicate significant improvement in COVID-19 detection using the proposed VAE based method. Furthermore, the ingenuity of the results have been established by performing Wilcoxon rank test with 95% level of significance.

10.
Eng Appl Artif Intell ; 122: 106130, 2023 Jun.
Artigo em Inglês | MEDLINE | ID: covidwho-2247906

RESUMO

The world is slowly recovering from the Coronavirus disease 2019 (COVID-19) pandemic; however, humanity has experienced one of its According to work by Mishra et al. (2020), the study's first phase included a cohort of 5,262 subjects, with 3,325 Fitbit users constituting the majority. However, among this large cohort of 5,262 subjects, most significant trials in modern times only to learn about its lack of preparedness in the face of a highly contagious pathogen. To better prepare the world for any new mutation of the same pathogen or the newer ones, technological development in the healthcare system is a must. Hence, in this work, PCovNet+, a deep learning framework, was proposed for smartwatches and fitness trackers to monitor the user's Resting Heart Rate (RHR) for the infection-induced anomaly. A convolutional neural network (CNN)-based variational autoencoder (VAE) architecture was used as the primary model along with a long short-term memory (LSTM) network to create latent space embeddings for the VAE. Moreover, the framework employed pre-training using normal data from healthy subjects to circumvent the data shortage problem in the personalized models. This framework was validated on a dataset of 68 COVID-19-infected subjects, resulting in anomalous RHR detection with precision, recall, F-beta, and F-1 score of 0.993, 0.534, 0.9849, and 0.6932, respectively, which is a significant improvement compared to the literature. Furthermore, the PCovNet+ framework successfully detected COVID-19 infection for 74% of the subjects (47% presymptomatic and 27% post-symptomatic detection). The results prove the usability of such a system as a secondary diagnostic tool enabling continuous health monitoring and contact tracing.

11.
Comput Struct Biotechnol J ; 21: 284-298, 2023.
Artigo em Inglês | MEDLINE | ID: covidwho-2239966

RESUMO

Since December 2019, the world has been intensely affected by the COVID-19 pandemic, caused by the SARS-CoV-2. In the case of a novel virus identification, the early elucidation of taxonomic classification and origin of the virus genomic sequence is essential for strategic planning, containment, and treatments. Deep learning techniques have been successfully used in many viral classification problems associated with viral infection diagnosis, metagenomics, phylogenetics, and analysis. Considering that motivation, the authors proposed an efficient viral genome classifier for the SARS-CoV-2 using the deep neural network based on the stacked sparse autoencoder (SSAE). For the best performance of the model, we explored the utilization of image representations of the complete genome sequences as the SSAE input to provide a classification of the SARS-CoV-2. For that, a dataset based on k-mers image representation was applied. We performed four experiments to provide different levels of taxonomic classification of the SARS-CoV-2. The SSAE technique provided great performance results in all experiments, achieving classification accuracy between 92% and 100% for the validation set and between 98.9% and 100% when the SARS-CoV-2 samples were applied for the test set. In this work, samples of the SARS-CoV-2 were not used during the training process, only during subsequent tests, in which the model was able to infer the correct classification of the samples in the vast majority of cases. This indicates that our model can be adapted to classify other emerging viruses. Finally, the results indicated the applicability of this deep learning technique in genome classification problems.

12.
7th International Conference on Sustainable Information Engineering and Technology, SIET 2022 ; : 199-206, 2022.
Artigo em Inglês | Scopus | ID: covidwho-2235970

RESUMO

In 2020, the world was attacked by a virus known as the COVID-19 virus. Restrictions on people's activities were conducted in various countries to prevent the spread of the virus. However, since people were vaccinated, restriction levels have been reduced or eliminated, although the new cases of COVID-19 worldwide have not ended. People's responses to restriction policies vary, including sentiment and human mobility. The possibility of sentiment is either support or resistance, while mobility is staying at home or not. This study analyzes the proportion between the two responses through two types of data: Text for sentiment and time series for mobility. Sentiment text data is taken from Twitter and mobility time series data is taken from Google Mobility for February 2020 to April 2022. Twitter and Google Mobility data are collected from several countries using English and implementing restrictions: Australia, Canada, Singapore, the United Kingdom (UK), and the United States (US). The unsupervised Autoencoder model is leveraged to find clusters. Two Autoencoder architectures are proposed for each data type. Before being used in Multilayer Autoencoder, text data is converted to vector data by Word2Vec. On the other hand, LSTM-Autoencoder is used for time series data. Finally, hypothesis tests are performed to determine the mean between the clusters formed is the same or different, out of five countries, only Canada has a null hypothesis is accepted, that means people in Canada tend to be neutral in response to COVID-19 while mobilities are dynamics, it reveals that people in Canada obey the government's decision on restrictions during the rise of COVID-19 cases. © 2022 ACM.

13.
2022 IEEE Conference on Telecommunications, Optics and Computer Science, TOCS 2022 ; : 183-186, 2022.
Artigo em Inglês | Scopus | ID: covidwho-2234630

RESUMO

Mask detection has become a hot topic since the COVID-19 pandemic began in recent years. However, most scholars only focus on the speed and accuracy of detection, and fail to pay attention to the fact that mask detection is not suitable for people living under extreme conditions due to the degraded image quality. In this work, a denoising convolutional auto-encoder, a multitask cascaded convolutional networks (MTCNN) and a MobileNet were used to solve the problem of mask detection for COVID-19 under extreme environments. First of all, a network based on AlexNet is designed for the auto-encoder. This study found that the two-layer max pooling layers in AlexNet could not accurately extract image features but damage the quality of restored image. Therefore, they were deleted, and other parameters such as channel number were also modified to fit the new net, and finally trained using cosine distance. In addition, for MTCNN, this study changed the output condition of ONet from thresholding to maximum return, and lowered the thresholds of PNet and RNet to solve the problem that faces might not be found in low-quality images with mask and other covers. Furthermore, MobileNet was trained using categorical cross entropy loss function with adam optimizer. In the end, the accuracy of system for the photos captured under extreme conditions enhance from 50 % to 85% in test images. © 2022 IEEE.

14.
2022 IEEE International Conference on E-health Networking, Application and Services, HealthCom 2022 ; : 19-24, 2022.
Artigo em Inglês | Scopus | ID: covidwho-2213185

RESUMO

In the current era of big data, very large amounts of data are generating at a rapid rate from a wide variety of rich data sources. Embedded in these big data are valuable information and knowledge that can be discovered by data science, data mining and machine learning techniques. Electronic health (e-health) records are examples of the big data. With the technological advancements, more healthcare practice has gradually been supported by electronic processes and communication. This enables health informatics, in which computer science meets the healthcare sector to address healthcare and medical problems. As a concrete example, there have been more than 610 millions cumulative cases of coronavirus disease 2019 (COVID-19) worldwide over the past 2.5 years since COVID-19 has declared as a pandemic. As some of these cases require hospitalization. it is important to estimate the demand in hospitalization. Moreover, different levels of hospitalization may require different types of resources (e.g., hospital beds, medical staff). For example, patients admitted into the intensive care unit (ICU) may require assisted ventilation. Hence, in this paper, we present models to make predictions based on e-health records. Specifically, our binary model predicts whether a patient require hospitalization, whereas our multi-class model predicts what level of hospitalization (e.g., regular ward, semi-ICU, ICU) is required by the patient. Our models uses few-shot learning (and may use multi-task learning) with autoencoders (comprising encoders and decoders) and a predictor. Evaluation results on real-life e-health records show the practicality of our models in predicting hospital statuses of COVID-19 cases and the benefits of these models towards effective allocation of resources (e.g., hospital facilities, staff). © 2022 IEEE.

15.
19th International Conference on Electrical Engineering, Computing Science and Automatic Control, CCE 2022 ; 2022.
Artigo em Inglês | Scopus | ID: covidwho-2213165

RESUMO

The COVID-19 outbreak is a major global catastrophe of our time and the largest hurdle since World War II. According to WHO, as of July 2022, there are more than 571 million confirmed cases of COVID-19 and over six million deaths. The issue of identifying unexpected inputs based on trained examples of normal data is known as anomaly detection. In the case of diagnosing covid-19, Chest X-ray disorders that are hardly apparent are extremely challenging to identify. Although various well-known supervised classification methods are being applied for that purpose, however in the real scenario, healthy patients' data is tremendously available but contaminated samples are scarce. The process of gathering samples from ill patients is troublesome and takes a lengthy time. To address the issue of data imbalance in anomaly detection, this research demonstrates an unsupervised learning technique using a convolutional autoencoder in which the training phase does not include any infected sample. Being trained only with the healthy data, The patterns of the healthy samples are preserved in latent vector space and can differentiate ill samples by observing substantial divergence from the distribution of healthy data. Higher reconstruction error and lower KDE (Kernel Density Estimation) indicate affected data. By contrasting the reconstruction error and KDE of healthy data with anomalous data, the suggested technique is feasible for identifying anomalous samples. © 2022 IEEE.

16.
IAES International Journal of Artificial Intelligence ; 11(4):1278-1286, 2022.
Artigo em Inglês | ProQuest Central | ID: covidwho-2203559

RESUMO

Millions of fatal cases have been reported worldwide as a result of the Coronavirus disease 2019 (COVID-19) outbreak. In order to stop the spreading of disease, early diagnosis and quarantine of infected people are one of the most essential steps. Therefore, due to the similar symptoms of SARS-CoV-2 virus and other pneumonia, identifying COVID-19 still exists some challenges. Reverse transcription-polymerase chain reaction (RT-PCR) is known as a standard method for the COVID-19 diagnosis process. Due to the shortage of RT-PCR toolkit in global, Chest X-Ray (CXR) image is introduced as an initial step to support patient's classification. Applying deep learning in medical imaging becomes an advanced research trend in many applications. In this research, RepVGG pre-trained model is considered to be used as the main backbone of the network. Besides, variational autoencoder (VAE) is firstly trained to perform lung segmentation. Afterwards, the encoder part in VAE is preserved as an additional feature extractor to combine with RepVGG performing classification. A COVID-19 radiography database consisting of 3 classes COVID-19, Normal and Viral Pneumonia is conducted. The obtained average accuracy of the proposed model is 95.4% and other evaluation metrics also show better results compared with the original RepVGG model.

17.
Electronics ; 12(1):105, 2023.
Artigo em Inglês | ProQuest Central | ID: covidwho-2199919

RESUMO

Artificial intelligence (AI), in particular deep learning, has proven to be efficient in medical diagnosis. This paper introduces a new hybrid deep learning model for pneumonia diagnosis based on chest CT scans. At the core of the model, a Gaussian mixture is combined with the expectation-maximization algorithm (EMGMM) to extract the regions of interest (ROI), while a convolutional denoising autoencoder (DAE) and deep restricted Boltzmann machine (DRBM) are combined for the classification. In order to prevent the model from learning trivial solutions, stochastic noises were added as an input to the unsupervised learning phase. The dataset used in this work is a publicly available dataset of chest X-rays for pneumonia on the Kaggle website;it contains 5856 images with 1583 normal cases and 4273 pneumonia cases, with an imbalance ratio (IR) of 0.46. Several operations including zooming, flipping, shifting and rotation were used in the augmentation phase to balance the data distribution across the different classes, which led to enhancing the IR value to 0.028. The computational analysis of the results show that the proposed model is promising as it provides an average accuracy value of 98.63%, sensitivity value of 96.5%, and specificity value of 94.8%.

18.
BMC Bioinformatics ; 24(1): 7, 2023 Jan 06.
Artigo em Inglês | MEDLINE | ID: covidwho-2196038

RESUMO

BACKGROUND: With the global spread of COVID-19, the world has seen many patients, including many severe cases. The rapid development of machine learning (ML) has made significant disease diagnosis and prediction achievements. Current studies have confirmed that omics data at the host level can reflect the development process and prognosis of the disease. Since early diagnosis and effective treatment of severe COVID-19 patients remains challenging, this research aims to use omics data in different ML models for COVID-19 diagnosis and prognosis. We used several ML models on omics data of a large number of individuals to first predict whether patients are COVID-19 positive or negative, followed by the severity of the disease. RESULTS: On the COVID-19 diagnosis task, we got the best AUC of 0.99 with our multilayer perceptron model and the highest F1-score of 0.95 with our logistic regression (LR) model. For the severity prediction task, we achieved the highest accuracy of 0.76 with an LR model. Beyond classification and predictive modeling, our study founds ML models performed better on integrated multi-omics data, rather than single omics. By comparing top features from different omics dataset, we also found the robustness of our model, with a wider range of applicability in diverse dataset related to COVID-19. Additionally, we have found that omics-based models performed better than image or physiological feature-based models, proving the importance of the omics-based dataset for future model development. CONCLUSIONS: This study diagnoses COVID-19 positive cases and predicts accurate severity levels. It lowers the dependence on clinical data and professional judgment, by leveraging the utilization of state-of-the-art models. our model showed wider applicability across different omics dataset, which is highly transferable in other respiratory or similar diseases. Hospital and public health care mechanisms can optimize the distribution of medical resources and improve the robustness of the medical system.


Assuntos
Teste para COVID-19 , COVID-19 , Humanos , COVID-19/diagnóstico , Aprendizado de Máquina , Redes Neurais de Computação , Modelos Logísticos
19.
New Gener Comput ; 40(4): 1053-1075, 2022.
Artigo em Inglês | MEDLINE | ID: covidwho-2148761

RESUMO

The new type of coronavirus disease, which has spread from Wuhan, China since the beginning of 2020 called COVID-19, has caused many deaths and cases in most countries and has reached a global pandemic scale. In addition to test kits, imaging techniques with X-rays used in lung patients have been frequently used in the detection of COVID-19 cases. In the proposed method, a novel approach based on a deep learning model named DeepCovNet was utilized to classify chest X-ray images containing COVID-19, normal (healthy), and pneumonia classes. The convolutional-autoencoder model, which had convolutional layers in encoder and decoder blocks, was trained by using the processed chest X-ray images from scratch for deep feature extraction. The distinctive features were selected with a novel and robust algorithm named SDAR from the deep feature set. In the classification stage, an SVM classifier with various kernel functions was used to evaluate the classification performance of the proposed method. Also, hyperparameters of the SVM classifier were optimized with the Bayesian algorithm for increasing classification accuracy. Specificity, sensitivity, precision, and F-score, were also used as performance metrics in addition to accuracy which was used as the main criterion. The proposed method with an accuracy of 99.75 outperformed the other approaches based on deep learning.

20.
Beijing Hangkong Hangtian Daxue Xuebao/Journal of Beijing University of Aeronautics and Astronautics ; 48(8):1495-1504, 2022.
Artigo em Chinês | Scopus | ID: covidwho-2145394

RESUMO

The continuous spread of the COVID-19 has brought profound impacts on human society. For the prevention and control of virus spreading, it is critical to predict the future trend of epidemic situation. Existing studies on COVID-19 spread prediction, based on classic SEIR models or naive time-series prediction models, are rarely considering the characteristics of complex regional correlation and strong time series dependence in the process of epidemic spread, which limits the performance of epidemic prediction. To this end, we propose a COVID-19 prediction model based on auto-encoder and spatiotemporal attention mechanism. The proposed model estimates the trend of COVID-19 by capturing the dynamic spatiotemporal dependence between the epidemic situation sequences of different regions. In particular, a spatial attention mechanism is implemented in the encoder section for every given region to capture the dynamic correlation between the epidemic situation time-series of the region and those of the related regions. Based on the leant correlation, an long short-term memory (LSTM) network is then applied to extract the epidemic sequential features for the given region by combining the recent epidemic situations of the region and the related regions. On the other hand, to better predict the dynamic of the future epidemic situation, temporal attention is introduced into an LSTM network-based decoder to capture the temporal dependence of the epidemic situation sequence. We evaluate the proposed model on several open datasets of COVID-19, and experimental results show that the proposed model outperforms the state-of-the-art models. The metrics of RMSE and MAE of the proposed model on the COVID-19 epidemic dataset of some European countries decreased 22. 3% and 25. 0%. The metrics of RMSE and MAE of the proposed model on the COVID-19 epidemic dataset of some Chinese provinces decreased 10. 1% and 10. 4%. © 2022 Beijing University of Aeronautics and Astronautics (BUAA). All rights reserved.

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